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SBE 13 hydrochloride

Product Name
SBE 13 hydrochloride
CAS No.
1052532-15-6
Chemical Name
SBE 13 hydrochloride
Synonyms
CS-1632;SBE-13 HCl;SBE13 HydrochL;SBE 13 hydrochloride;SBE 13 hydrochloride USP/EP/BP;SBE 13 hydrochloride >=98% (HPLC);N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine;N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine;N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride;N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
CBNumber
CB82552606
Molecular Formula
C24H28Cl2N2O4
Formula Weight
479.4
MOL File
1052532-15-6.mol
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SBE 13 hydrochloride Property

storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: ≥17mg/mL
form 
powder
color 
white to tan
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0012
Product name
SBE 13 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2022/05/15
Cayman Chemical
Product number
21241
Product name
SBE 13 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
21241
Product name
SBE 13 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
21241
Product name
SBE 13 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$232
Updated
2024/03/01
Cayman Chemical
Product number
21241
Product name
SBE 13 (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$421
Updated
2024/03/01
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SBE 13 hydrochloride Chemical Properties,Usage,Production

Description

SBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC50 = 0.2 nM) that targets the inactive conformation of the enzyme . It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC50 > 66 μM) and Plk3 (IC50 = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC50 = 5-60 μM), and induces apoptosis in a broad range of human cancer cell lines.

Uses

SBE13 Hydrochloride is a selective inhibitor of PLK1.

in vitro

to determine its ability to induce cell death in cancer cells, we applied kinase assays, western blot analyses, facs can analyses, caspase assays and immunofluorescence studies. we detected decreased cell proliferation, delayed progression through the cell cycle in lower sbe13 concentrations, a g2/m arrest using higher sbe13 concentrations followed by apoptosis, and abnormal mitotic figures. notably, sbe13 did not influence activity of other kinases (plk2, plk3, aurora a), indicating the selectivity of this type ii plk1 inhibitor [1].

SBE 13 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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SBE 13 hydrochloride Suppliers

China 61 United Kingdom 1 United States 13 Global 75
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
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View Lastest Price from SBE 13 hydrochloride manufacturers

Career Henan Chemical Co
Product
N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine,hydrochloride 1052532-15-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

1052532-15-6, SBE 13 hydrochlorideRelated Search:

SBE13

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  • SBE-13 HCl
  • N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
  • N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
  • CS-1632
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  • SBE 13 hydrochloride >=98% (HPLC)
  • SBE 13 hydrochloride USP/EP/BP
  • N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine
  • Inhibitor,SBE13,Apoptosis,Polo-like Kinase (PLK),inhibit,SBE13 Hydrochloride,SBE 13,SBE-13 Hydrochloride,Autophagy,SBE-13
  • 1052532-15-6
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